Do you use a Symbol Server?
I find one of the most often overlooked new features of 2010 is the Symbol Server. This is a file share where the .PDB symbol files are stored for any given build (generated by a build server, see Jim Lamb’s post on the setup). If you look on the symbol server share you will see directories for each built assembly with a GUID named subdirectory containing the PDB files for each unique build. ...